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Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting.

Geoffroy CG*, Meves JM, Mun Kim HJ, Romaus-Sanjurjo D, Sutherland TC, Li JJ, Suen J, Sanchez JJ, Zheng B*. * co-corresponding authors. iScience, 2022 Nov 18;25(11):105383. 


In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system.

Allen JK, Sutherland TC, Prater AR, Geoffroy CG*, Pellois JP*. * co-corresponding authors. Science Advances. 2022 Sep 28;8(39):eabo2954. 


Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury. 

Dietz VA, Roberts N, Knox K, Moore S, Pitonak M, Barr C, Centeno J, Leininger S, New KC, Nowell P, Rodreick M, Geoffroy CG, Stampas A, Dulin JN.  Frontiers in Cellular Neuroscience. 2022 Sep 7;16:462.


Novel Adult Cortical Neuron Processing and Screening method illustrates Sex- and Age-dependent effects of pharmaceutical compounds.

Sefiani A, Rusyn I, Geoffroy CG*. Sci. Rep. 12 (1), 13125. 2022. 

Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice.

Ghnenis, A.B.; Jones, C.; Sefiani, A.; Douthitt, A.J.; Reyna, A.J.; Rutkowski, J.M.; Geoffroy, C.G.  Biology 2022, 11, 495.

Osteopenia in a Mouse Model of Spinal Cord Injury: Effects of Age, Sex and Motor Function.

Hook, M.A.; Falck, A.; Dundumulla, R.; Terminel, M.; Cunningham, R.; Sefiani, A.; Callaway, K.; Gaddy, D.; Geoffroy, C.G. . Biology 2022, 11, 189.

Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons. 

Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG*. Cells. 2021 Jun 29;10(7). doi: 10.3390/cells10071625. 

The potential role of inflammation in modulating endogenous hippocampal neurogenesis after spinal cord injury 

Sefiani A, Geoffroy CG- Front Neurosci. 2021;15:682259. Published 2021 Jun 18. doi:10.3389/fnins.2021.682259

Are mitochondria the key to reduce the age-dependent decline in axon growth after spinal cord injury?

Sutherland TC, Geoffroy CG, Neural Regen Res 2021;16:1444-5

A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.

Salem NA, Mahnke AH Tseng AM Garcia CRJahromi HKGeoffroy CGMiranda RC Neurotoxicol Teratol​,. Jan-Feb 2021;83:106943. doi:10.1016/ Epub 2020 Nov 20.

Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury.

Sutherland TC, Geoffroy CG. Front Cell Dev Biol. 2020;8:190. Published 2020 Mar 25. doi:10.3389/fcell.2020.00190

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice

Xu J et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020;5(3):e131277. Published 2020 Feb 13. doi:10.1172/jci.insight.131277


Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury.

Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. Experimental neurology. 2018; 309:32-43. NIHMSID: NIHMS1502842 PubMed [journal] PMID:30055160, PMCID: PMC6139267

Adult rat myelin enhances axonal outgrowth from neural stem cells.

Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. Science translational medicine. 2018; 10(442). PubMed [journal] PMID: 29794059. DOI: 10.1126/scitranslmed.aal2563

Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS.

Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B. Cell reports. 2018; 22(13):3587-3597. NIHMSID: NIHMS957794 PubMed [journal] PMID: 29590625, PMCID: PMC5905706.

The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.

Geoffroy CG, Meves JM, Zheng B. Neuroscience letters. 2017; 652:41-49. NIHMSID: NIHMS828683 PubMed [journal] PMID: 27818358, PMCID: PMC5415436

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.

Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. Scientific reports. 2016; 6:31482. PubMed [journal] PMID: 27511108, PMCID: PMC4980599


Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System.

Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. Cell reports. 2016; 15(2):238-46. NIHMSID: NIHMS769142 PubMed [journal] PMID: 27050519, PMCID: PMC5050004

The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease.

Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. Current pathobiology reports. 2016; 4(1):27-35. NIHMSID: NIHMS761714 PubMed [journal] PMID: 27239399, PMCID: PMC4878828

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice.

Geoffroy CG, Lorenzana AO, Kwan JP, Lin K, Ghassemi O, Ma A, Xu N, Creger D, Liu K, He Z, Zheng B. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015; 35(16):6413-28. PubMed [journal] PMID: 25904793, PMCID: PMC4405557

Myelin-associated inhibitors in axonal growth after CNS injury.

Geoffroy CG, Zheng B. Current opinion in neurobiology. 2014; 27:31-8. NIHMSID: NIHMS567337 PubMed [journal] PMID: 24608164, PMCID: PMC4122599


NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.

Dickendesher TL, Baldwin KT, Mironova YA, Koriyama Y, Raiker SJ, Askew KL, Wood A, Geoffroy CG, Zheng B, Liepmann CD, Katagiri Y, Benowitz LI, Geller HM, Giger RJ. Nature neuroscience. 2012; 15(5):703-12. NIHMSID: NIHMS357951 PubMed [journal] PMID: 22406547, PMCID: PMC3337880

Role of myelin proteins on axon regeneration and sprouting

Geoffroy CG. Medecine sciences : M/S. 2011; 27(2):132-5. PubMed [journal] PMID: 21382319


Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice.

Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B. Neuron. 2010; 66(5):663-70. NIHMSID: NIHMS206496 PubMed [journal] PMID: 20547125, PMCID: PMC2896331

Generation of an EphA4 conditional allele in mice.

Herrmann JE, Pence MA, Shapera EA, Shah RR, Geoffroy CG, Zheng B. Genesis (New York, N.Y. : 2000). 2010; 48(2):101-5. NIHMSID: NIHMS167068 PubMed [journal] PMID: 20014422, PMCID: PMC2819605

Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues.

Geoffroy CG, Critchley JA, Castro DS, Ramelli S, Barraclough C, Descombes P, Guillemot F, Raineteau O. Stem cells (Dayton, Ohio). 2009; 27(4):847-56. PubMed [journal] PMID: 19350686

A Cre-lox approach for transient transgene expression in neural precursor cells and long-term tracking of their progeny in vitro and in vivo.

Geoffroy CG, Raineteau O. BMC developmental biology. 2007; 7:45. PubMed [journal] PMID: 17504531, PMCID: PMC1885435

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